A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema

This trial is testing a procedure called bronchoscopic thermal vapor ablation (BTVA) — a minimally invasive treatment delivered through a breathing tube — for people with severe emphysema (a type of COPD where the air sacs in the lungs are permanently damaged). The procedure uses steam to treat specific areas of the lung, aiming to improve breathing. **You may be eligible if...** - You are 18 years or older - You have severe emphysema and specific treatable areas in your lungs identified by CT scan - You have not smoked for at least 2 months and will not smoke during the study - Your lung function tests show severe obstruction (FEV1 between 15% and 50% predicted) - You can walk at least 140 meters in 6 minutes - You experience significant breathlessness (mMRC score ≥ 2) **You may NOT be eligible if...** - You have had a recent heart attack, very low heart function, or serious heart rhythm problems - You have active bleeding in the airways, blood clotting disorders, or severe lung high blood pressure - You have recently had a COPD flare-up (within the past 6 weeks) - You have had previous lung surgery, lung volume reduction surgery, or lung transplant - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.