ULtrafiltration-Rate Induced CArdiac Strain (ULRICA) - Study
The Effect of Hemodialysis on proBNP
Umeå University
40 participants
Mar 20, 2023
INTERVENTIONAL
Conditions
Summary
Patients performing chronic hemodialysis (HD) retain more or less water between dialyses. The water is removed by ultrafiltration and usually during the cleansing of waste products - the HD. The length of HD is usually the same as the time of fluid removal while sometimes this may differ. There is no clear guideline. In previous research the investigator noted that the heart releases more NT-pro-BNP during HD in numerous of the patients. The present study aims to clarify if the speed of fluid removal during HD is a factor that may alter the release of cardiac markers during HD. If so the recommendations for the prescription of HD can be updated.
Eligibility
Inclusion Criteria3
- Adult HD patients with an intra-dialytic weight gain (IDWG) ≥2.5% of target weight over the long interval (3 days) prior to inclusion.
- Patients need to be able to understand the study information
- Patients need to be able to give consent.
Exclusion Criteria2
- Active systemic inflammatory state such as extensive malignancy or acute septic infection.
- Uncontrolled hyperphosphatemia decided by the local routine of the physician (due to somewhat decreased efficacy of the low flux filter to eliminate phosphate)
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Interventions
Fluid removal during HD will be linear. The time on HD for fluid removal is adjusted after a formula for interdialytic weight gain / removal time (see Goto et al 2023).
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06153888