RecruitingNot ApplicableNCT06154174

Choline to Improve Malnutrition and Enhance Cognition


Sponsor

Washington University School of Medicine

Enrollment

1,500 participants

Start Date

Dec 5, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this clinical trial is to test adding choline to ready-to-use therapeutic food (RUTF) in children with severe acute malnutrition (SAM) in Malawi. The main question it aims to answer is: \- Will the addition of a 500mg daily dose of choline to RUTF during treatment for SAM improve cognitive development among 6-59-month-old Malawian children compared with standard RUTF without added choline?


Eligibility

Min Age: 6 MonthsMax Age: 59 Months

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Amoxicillin, C-RUTF (Ready-to-Use Therapeutic Food with added choline), and others for people with cognitive impairment, kwashiorkor, and other related conditions. The study is currently recruiting participants at 10 locations.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIETARY_SUPPLEMENTC-RUTF (Ready-to-Use Therapeutic Food with added choline)

Choline added to peanut paste-based ready-to-use therapeutic food meeting Codex Alimentarius specifications

DIETARY_SUPPLEMENTS-RUTF (Ready-to-Use Therapeutic Food without added choline)

Standard peanut paste-based ready-to-use therapeutic food meeting Codex Alimentarius specifications

DRUGAmoxicillin

Oral amoxicillin tablets twice per day for 7 days dosed based on weight


Locations(10)

Makhwira

Makhwira, Chikwawa, Malawi

Mitondo

Mitondo, Chikwawa, Malawi

Nkhate

Nkhate, Chikwawa, Malawi

Chipolonga

Chipolonga, Machinga, Malawi

Chikonde

Chikonde, Mulanje, Malawi

Mbiza

Mbiza, Mulanje, Malawi

Milonde

Milonde, Mulanje, Malawi

Muloza

Muloza, Mulanje, Malawi

Namasalima

Namasalima, Mulanje, Malawi

Naphimba

Naphimba, Mulanje, Malawi

View Full Details on ClinicalTrials.gov

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NCT06154174


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