Clinical Outcomes and Pharmacotherapy Effectiveness in the VA Health Care System (COPE-VA)
CSP #2038 - COVID-19 Pharmacotherapy Effectiveness in the VA Healthcare System (COPE-VA)
VA Office of Research and Development
400,000 participants
Sep 26, 2022
OBSERVATIONAL
Conditions
Summary
The purpose of this study is to comprehensively describe the temporal and geographic utilization of COVID-19 therapies used for mild to moderate disease during different periods of SARS-CoV-2 variant circulation as well as to compare demographic and clinical characteristics of Veterans who are treated or do not receive these different therapies. The investigators will also perform similar descriptive epidemiology for other respiratory viruses, including RSV and influenza and other infectious diseases. This first phase will critically inform feasibility and direction of the second phase, in which the investigators will use target trial emulation design to study the comparative effectiveness of therapies and vaccines for COVID-19, respiratory viruses, including RSV, and influenza, and other infectious diseases.
Eligibility
Inclusion Criteria4
- Phase 1:
- \- Veterans aged 18 years with a laboratory-confirmed positive test for SARS-CoV-2 or a diagnosis of COVID-19 documented at any time since the beginning of the pandemic in January 2020 to present.
- Phase 2:
- All Veterans aged 18 years alive and in VHA care as of January 2018.
Exclusion Criteria1
- VA employees who are not enrollees
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Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06160128