RecruitingNCT06163612

Effect of Suicidality on Social Cognition

Effect of Suicidality in Major Depressive Disorder During Social Cognition

Sponsor

Unity Health Toronto

Enrollment

150 participants

Start Date

Sep 1, 2022

Study Type

OBSERVATIONAL

Conditions

Suicide Major Depressive Disorder

Summary

Major Depressive Disorder (MDD) is a very common illness that is usually treated with antidepressant medication. Depression can be caused by many things such as childhood experiences, genetics, and changes in the way the body and brain function. It is most likely caused by a combination of several of these factors. The prevalence of suicide attempt in Major Depressive Disorder (MDD) is about 20%. Risk for suicide attempt can be increased by many things such as negative life events, genetics, and changes in the way the body and brain function. It is most likely caused by a combination of several of these factors. In this study, the investigators will be collecting detailed information about participants' psychiatric history and depression symptoms, as well as brain scans. The goal is to use this information to help us determine what predicts suicide attempt history.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study examines how thinking about or experiencing suicidal thoughts affects a person's ability to understand and interpret the emotions and intentions of others (called social cognition). Researchers will compare people with and without recent suicidal thoughts on various psychological tasks. **You may be eligible if...** - You are an adult (18+) - You either have a history of suicidal thoughts or attempts (clinical group) or have no such history (healthy comparison group) - You are willing and able to complete psychological assessments **You may NOT be eligible if...** - You have a neurological condition that would affect cognitive testing - You are currently in acute psychiatric crisis - You have impairment (due to medications or substance use) that would affect test results on the day of assessment Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALClinical Interview

A study team member will meet the participant to ask questions regarding the degree of depression at the beginning of the study. This interview will take approximately 1 hour.

BEHAVIORALClinical Questionnaires

A study team member will ask the participant to complete questionnaires assessing the severity of the participant's depression, daily activities, personality/traits, and quality of life. If the participant opts to complete these questionnaires at home, they will be emailed them within 24 hours of this visit. These questionnaires will take approximately 1-2 hours.

OTHERBrain Scan

The participant will be asked to undergo a magnetic resonance imaging (MRI) scan to look at the structure and function of their brain. The functional MRI measures the level of blood flow to areas of the brain associated with mood and behaviour, and the participant will be asked to complete two behavioural games while they are in the scanner. During the scan, the participant will be required to lie on a table within the cylindrical tube of the MRI scanner in order to complete the scan. This will result in limited movement for the duration of the scan. The scan will take approximately 60 minutes.

BEHAVIORALBehavioural Games

The participant will be asked to complete two behavioural games inside the scanner. One of these games includes a monetary payout. They will be given instructions about these tasks outside of the scanner.