NBI Combined With MRI to Guide CTV Optimization in Eccentric Nasopharyngeal Carcinoma
Endoscopic NBI Combined With MRI to Guide the Optimization of Clinical Target Volume Delineation in Eccentric Nasopharyngeal Carcinoma
Chongqing University Cancer Hospital
60 participants
Oct 20, 2023
INTERVENTIONAL
Conditions
Summary
This is a prospective, single-center clinical trial in eccentric nasopharyngeal carcinoma (NPC) patients. The aim of this study is to evaluate the efficacy and safety of NBI combined with MRI-guided optimized CTV compared with conventional CTV, and to compare the radiotherapy-related adverse events and quality of life between the two groups.
Eligibility
Inclusion Criteria8
- Males and females ≥18 years of age;
- ECOG Performance Status 0,1 or 2;
- Pathologically diagnosed as nasopharyngeal carcinoma;
- Pretreatment nasopharynx and neck MRI imaging;
- Nasopharyngeal suspected lesions were examined by NBI endoscopy;
- Meeting the definition of eccentric NPC with ipsilateral (affected side) staging of T1-4 and contralateral (healthy side) staging of T0;
- Patients evaluated without contraindications to radiotherapy;
- Voluntary participation in clinical research, and signed informed consent.
Exclusion Criteria5
- Patients who did not successfully undergo all three examinations (MRI, NBI, and endoscopic biopsy);
- Other rare pathological types, such as adenocarcinoma;
- Patients with tumor invasion of the clivus;
- Patients whose contralateral retropharyngeal lymph nodes met the diagnostic criteria;
- Invasion of paranasal sinuses (except simple sphenoid invasion).
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Interventions
The contralateral CTV1 was defined as a subclinical disease consisting of 5mm margin surrounding GTVnx.The CTV2 was defined as a potentially involved regions consisting of 5mm margin surrounding CTV1, and contralateral CTV2 only included the pharyngeal recess.
Locations(1)
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NCT06167109