RecruitingPhase 2NCT06509009

Nimotuzumab Combined With TGP as First-line Therapy in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma

Nimotuzumab Combined With Toripalimab/Gemcitabine/Cisplatin as First-line Therapy in Patients With Recurrent/Metastatic Nasopharyngeal Carcinoma: a Prospective, Single-arm, Phase II Clinical Study


Sponsor

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

Enrollment

30 participants

Start Date

Aug 30, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this study is to learn the efficacy and safety of nimotuzumab combined with toripalimab and gemcitabine/cisplatin regimen treatment recurrent/distant-metastasis nasopharyngeal carcinoma.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a combination of two drugs — nimotuzumab (a targeted antibody) and TGP (a plant-based chemotherapy drug) — as a first-line treatment for patients with nasopharyngeal carcinoma (cancer at the back of the nose and throat) that has come back or spread to other parts of the body. **You may be eligible if...** - You are between 18 and 75 years old - You have been diagnosed with recurrent or metastatic nasopharyngeal carcinoma confirmed by biopsy - This is your first treatment for recurrent or metastatic disease (you have not yet received systemic therapy for the spread) - Your tumor tests positive for a protein called EGFR - You have at least one measurable tumor lesion - You are in reasonably good health (ECOG 0 or 2) and expected to survive at least 3 months **You may NOT be eligible if...** - You have already received systemic treatment for your recurrent or metastatic disease - Your tumor is EGFR-negative - You have serious heart, liver, kidney, or blood problems Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGNimotuzumab

nimotuzumab, toripalimab, gemcitabine, cisplatin


Locations(1)

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medcial Science and Peking Union Medical College

Beijing, Beijing Municipality, China

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NCT06509009


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