RecruitingEarly Phase 1NCT06168461

Daily Aspirin Treatment After Preeclampsia

Aspirin for the Treatment of Vascular Dysfunction After Preeclampsia


Sponsor

Anna Stanhewicz, PhD

Enrollment

40 participants

Start Date

Nov 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

Women who develop preeclampsia during pregnancy are four times more likely to develop cardiovascular disease later in life, even if they are otherwise healthy. The reason why this occurs may be related to lasting blood vessel damage after the pregnancy but there are currently no specific treatment strategies to prevent this disease progression. This study addresses this public health issue by examining whether starting low dose aspirin therapy after pregnancy is an effective treatment for lasting blood vessel damage in order to inform better clinical management of cardiovascular disease risk in women who have had preeclampsia.


Eligibility

Sex: FEMALEMin Age: 18 YearsMax Age: 50 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether low-dose daily aspirin can reduce the risk of cardiovascular disease in women who had preeclampsia (dangerously high blood pressure during pregnancy), since these women have a higher long-term risk of heart problems. **You may be eligible if...** - You had preeclampsia within the past 5 years - You are 18 years or older **You may NOT be eligible if...** - You are already taking daily aspirin - You smoke or use any nicotine products (including vaping) - You have chronic kidney disease, liver disease, or metabolic disorders - You are currently taking cholesterol-lowering medications, blood pressure medications, or had high blood pressure before pregnancy - You have a history of gestational diabetes - You are currently pregnant - You have a BMI below 18.5 - You have a bleeding disorder, stomach ulcers, gastritis, GI bleeding, or severe acid reflux - You have known allergies to study medications or latex Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGAspirin

162mg aspirin capsule

DRUGPlacebo

placebo capsule


Locations(1)

University of Iowa

Iowa City, Iowa, United States

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NCT06168461


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