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RecruitingNot ApplicableNCT06178315

EUS-guided Celiac Plexus Block vs. Sham in Chronic Pancreatitis

Randomized Trial of EUS-guided Celiac Plexus Block vs. Sham for Palliation of Pain in Chronic Pancreatitis

Sponsor

Orlando Health, Inc.

Enrollment

94 participants

Start Date

Dec 7, 2023

Study Type

INTERVENTIONAL

Conditions

Chronic Pancreatitis

Summary

The aim of this randomized trial is to assess the efficacy of EUS-CPB in the alleviation of abdominal pain in patients with chronic pancreatitis.

Eligibility

Min Age: 18 Years

Inclusion Criteria4

  • Age ≥ 18 years
  • Abdominal pain of at least 3 months duration and a VAS score ≥ 3, with or without the use of narcotic analgesics.
  • Diagnosis of chronic pancreatitis on EUS examination, with ≥ 5 features on EUS.
  • No other cause of abdominal pain

Exclusion Criteria6

  • Age < 18 years.
  • History of prior EUS-CPB.
  • Use of anticoagulants that cannot be discontinued for the procedure.
  • Clinically significant allergy to bupivacaine or triamcinolone.
  • Unable to obtain consent for the procedure from either the patient or LAR.
  • Intrauterine pregnancy.

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Interventions

PROCEDUREEUS-guided celiac plexus block

Under EUS-guidance, celiac plexus block will be performed with injection of bupivacaine and triamcinolone into the area of celiac plexus.

PROCEDURESham procedure

Celiac plexus will not be performed in this arm.

Locations(1)

Orlando Health

Orlando, Florida, United States

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NCT06178315

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