RecruitingEarly Phase 1NCT06181513

Probiotics in Mild Alzheimer's Disease

Effect of Probiotics on Cognitive Functioning of Patients With Mild Alzheimer's Disease


Sponsor

University of Nicosia

Enrollment

40 participants

Start Date

Dec 19, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

The main objective is to investigate whether administration of probiotics to patients with mild Alzheimer's Disease (AD) reduces neuroinflammation, improves cognitive function and modifies neurophysiological measures, compared to a patient group that receives placebo (no active probiotics).


Eligibility

Min Age: 65 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study tests whether taking a probiotic supplement (beneficial bacteria) can slow memory and thinking decline in people with mild Alzheimer's disease. The gut-brain connection is increasingly understood to play a role in brain health, and this trial examines whether improving gut bacteria has any effect on cognitive symptoms. **You may be eligible if...** - You are 65 years or older - You have been diagnosed with mild Alzheimer's disease, confirmed by a memory test score between 19 and 23 (on the MMSE scale) - You are able to give informed consent yourself **You may NOT be eligible if...** - You are unable to give informed consent independently - You have another neurological disease in addition to Alzheimer's (such as Parkinson's disease or stroke) - You are already taking probiotics regularly - Your Alzheimer's is moderate or severe (not mild) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGProbiotic Blend Capsule

20 million CFU (Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus helveticus, Bifidobacterium breve)


Locations(1)

The Cyprus Institute of Neurology and Genetics

Nicosia, Cyprus

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NCT06181513


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