Real-world Clinical Response to Trazodone in Italy, Poland, and Romania

This real-world study tracks how well trazodone (an antidepressant) works in older adults with both moderate-to-severe major depressive disorder (depression) and mild cognitive impairment (early memory or thinking problems) in Italy, Poland, and Romania. **You may be eligible if...** - You are 55 years old or older - You have been diagnosed with major depressive disorder according to DSM-5 criteria - Your depression is at least moderately severe (as measured by a standard rating scale) - You also have a diagnosis of mild cognitive impairment - You are starting trazodone treatment at or near the time of enrollment - You are legally capable of providing written consent **You may NOT be eligible if...** - You have a medical contraindication to trazodone - You are allergic to trazodone - You are already on other antidepressants, mood stabilizers, or antipsychotics alongside trazodone - You have bipolar disorder, schizophrenia, severe personality disorder, or intellectual disability - You have a history of suicide attempts or self-harm Talk to your doctor to see if this trial is right for you.