Finding the Best Tamoxifen Dose for Breast Cancer Risk Reduction in Premenopausal Women, RENAISSANCE Trial

This trial (called RENAISSANCE) is trying to find the best low dose of tamoxifen — a hormone-blocking medication — that can reduce breast cancer risk in premenopausal women while causing fewer side effects than the standard full dose. **You may be eligible if...** - You are a premenopausal woman (still having regular periods or on hormonal contraception with at least one ovary) - You are under 50 years of age - You are at increased risk of breast cancer (for example, due to family history, a previous abnormal breast biopsy, or genetic risk factors) - You are not currently pregnant or breastfeeding **You may NOT be eligible if...** - You have already been diagnosed with invasive breast cancer - You have a history of blood clots or stroke - You are currently taking other hormonal treatments that cannot be stopped - You are postmenopausal Talk to your doctor to see if this trial is right for you.