COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascular and Peribiliary Colorectal Liver Metastases

This trial (COLDFIRE-III) tests a combination of two treatments — irreversible electroporation (a non-heat-based tumor destruction technique) and stereotactic body radiotherapy (highly targeted radiation) — for people with colorectal cancer that has spread to the liver in locations that are too close to blood vessels or bile ducts for standard surgery or heat-based ablation. **You may be eligible if...** - You have been diagnosed with colorectal cancer that has spread to your liver (1–3 spots, each up to 5 cm) - Your liver spots cannot be removed surgically or treated with heat ablation because of their location near blood vessels or bile ducts - You have had prior treatment for colorectal cancer - You may have a limited number of additional liver spots that are treatable separately **You may NOT be eligible if...** - You have more than 10 liver spots total - Your cancer has spread widely beyond the liver and is uncontrolled - You have serious heart or clotting disorders - You are pregnant Talk to your doctor to see if this trial is right for you.