Novel Magnetic Resonance Imaging-Guided Ultrasound-Stimulated Microbubble Radiation Treatment for Patients With Chest-Wall and Breast Cancer

This study tests a new approach that combines MRI-guided focused ultrasound with tiny gas-filled bubbles (microbubbles) to make breast or chest-wall cancer tumors more sensitive to radiation therapy. The goal is to improve treatment effectiveness without increasing side effects. **You may be eligible if...** - You are 18 or older - You have biopsy-confirmed invasive breast cancer (any type) - You have early-stage, locally advanced, or metastatic breast cancer (Stage IIA to Stage IV) - A multidisciplinary medical team has recommended you as a candidate for this combined treatment approach **You may NOT be eligible if...** - You have a pacemaker or other implanted device incompatible with MRI - You have a known allergy to ultrasound contrast agents (microbubbles) - You have serious heart or lung problems - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.