RecruitingNCT06186089

Effect of Gastrectomy on Gut Microbiome and Cognitive Function

Effects of Total Gastrectomy or Double Track Reconstruction on Gut Microbiome and Cognitive Function in Patients With Proximal Gastric Cancer

Sponsor

Jiangjiang Bi

Enrollment

45 participants

Start Date

Jan 20, 2024

Study Type

OBSERVATIONAL

Conditions

Gastric Cancer Perioperative Neurocognitive Disorders

Summary

Perioperative neurocognitive disorders is a common postoperative complication in elderly surgical patients. The role of gut microbiota in cognitive function has been concerned in recent years. Studies suggests that gastrointestinal surgery may affect the gut microbiota, and the effect varies between surgical procedures. In this study, the investigators will compare the differences of gut microbiota between total gastrectomy and double-tract reconstruction, to investigate the effect of gastric acid on the gut microbiota colonizing, and the effect of different surgical procedures on the postoperative cognitive function of proximal gastric cancer patients.

Eligibility

Min Age: 40 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study examines how stomach removal surgery (gastrectomy) for proximal gastric cancer affects the gut microbiome (the bacteria in your digestive system) and cognitive function (thinking, memory) over time. It is an observational study to better understand these connections. **You may be eligible if...** - You are between 40 and 80 years old - You have been diagnosed with proximal (upper) gastric cancer and are scheduled for gastrectomy - You are in generally acceptable health for surgery (ASA classification I–III) - You are awake and alert before the operation **You may NOT be eligible if...** - You have a neurological or psychiatric disorder - You have been regularly using sedatives or antidepressants in the past year - You have Parkinson's disease - You have severe hearing or vision impairment that limits communication Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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