Effect of Gastrectomy on Gut Microbiome and Cognitive Function
Effects of Total Gastrectomy or Double Track Reconstruction on Gut Microbiome and Cognitive Function in Patients With Proximal Gastric Cancer
Jiangjiang Bi
45 participants
Jan 20, 2024
OBSERVATIONAL
Conditions
Summary
Perioperative neurocognitive disorders is a common postoperative complication in elderly surgical patients. The role of gut microbiota in cognitive function has been concerned in recent years. Studies suggests that gastrointestinal surgery may affect the gut microbiota, and the effect varies between surgical procedures. In this study, the investigators will compare the differences of gut microbiota between total gastrectomy and double-tract reconstruction, to investigate the effect of gastric acid on the gut microbiota colonizing, and the effect of different surgical procedures on the postoperative cognitive function of proximal gastric cancer patients.
Eligibility
Inclusion Criteria4
- Clinical diagnosis of proximal gastric cancer and will be performed gastrectomy
- American Society of Anesthesiologists (ASA) classification I-III
- Aged 40-80 years
- Perioperative consciousness
Exclusion Criteria7
- Central nervous system and psychological disorders
- Chronic use of sedatives, antidepressants within the last year
- Parkinson's disease
- Severe immunosuppression
- Severe hearing or vision impairment
- Drug dependence; alcoholism
- Inability to communicate with a physician
Interventions
patients undergoing total gastrectomy take probiotics qd for 3 months
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06186089