RecruitingPhase 2NCT06189820
Role of the Fibroblast Activation Protein (FAP) as Biomarker of Fibrotic Lung Diseases
Sponsor
Erasme University Hospital
Enrollment
70 participants
Start Date
Mar 9, 2023
Study Type
INTERVENTIONAL
Conditions
Summary
To evaluate the effect of an anti-fibrotic treatment initiation on the fibrotic activity as assessed by FAPI PET/CT.
Eligibility
Min Age: 18 Years
Inclusion Criteria1
- Adults patients with a fibrotic lung disease (idiopathic pulmonary fibrosis (IPF) or non-IPF fibrotic ILD) as defined according to the 2022 ATS/ERS/JRS/ALAT Clinical Practice Guidelines
Exclusion Criteria3
- Pregnant or nursing patients
- Patients with another significant medical condition which, in the investigator's opinion, may interfere with the completion of the study.
- Patients with an active lung neoplasm or any active neoplasm for blood samples
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Interventions
DIAGNOSTIC_TESTFAPI PET/CT
In the department of Nuclear Medicine: * Installation in a relax chair after weight and height control * Placement of a venous line in the upper limb after which an infusion of 500ml of 0.9% NaCl is started. * Intravenous injection of 3 MBq/kg (max 300 MBq) of 18F- FAPI 74 or of 2 MBq/kg 68Ga-FAPI46
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06189820
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