RecruitingNCT06196086

Myocardial Stiffness Evaluation in Patients With Heart Failure With Preserved Ejection Fraction

Evaluation of Myocardial Stiffness in Patients With Heart Failure With Preserved Ejection Fraction by Intrinsic Wave Velocity Propagation

Sponsor

Haiyan Wang

Enrollment

438 participants

Start Date

Dec 20, 2023

Study Type

OBSERVATIONAL

Conditions

Heart Failure With Preserved Ejection Fraction

Summary

The goal of this observational study is to evaluating myocardial stiffness in patients with heart failure with preserved ejection fraction (HFpEF) by intrinsic wave velocity propagation (IVP). The main questions it aims to answer are: * Whether myocardial stiffness assessed by IVP in patients with HFpEF Increased. * Whether IVP is related to the cardiac structure and function in patients with HFpEF. * What are the risk factors that may be associated with heart failure rehospitalization in patients with HFpEF? * Whether increased myocardial stiffness is a risk factor for heart failure rehospitalization. Participants will undergo transthoracic echocardiography to obtain conventional ultrasound parameters, and software post-processing analysis to obtained two-dimensional strain parameters and IVP, as well as general clinical data and laboratory test results. Clinical followed up was performed through electronic medical records or telephone interviews until patient rehospitalization for heart failure or discharge for one year.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Inclusion Criteria4

Meet the diagnostic criteria for HFpEF in the 2022 AHA/ACC/HFSA Guidelines for Heart Failure Management:
Present with signs and symptoms of heart failure;
LVEF≥50%;
There is at least one additional criterion: Increased BNP (BNP≥35pg/ml, NT-pro BNP\>125pg/ml) and resting echocardiography measured E/e' ≥ 15; Stress echocardiography determined E/e' ≥ 15; Cardiac catheterization at rest, PCWP ≥ 15 mmHg or LVEDP ≥ 16 mmHg; The PCWP at peak exercise was ≥ 25 mmHg.

Exclusion Criteria4

Acute coronary syndrome, acute heart failure or coronary revascularization in three months;
HFimpEF, cardiomyopathy, severe valvular heart disease, arrhythmia;
Thyroid dysfunction, pulmonary hypertension, past or current pulmonary embolism, severe chronic obstructive pulmonary disease, malignancy/renal failure (less than 30) ml/min);
Poor echocardiogram image quality.

Interventions

DIAGNOSTIC_TESTEchocardiography examination

Echocardiography examination and software post-processing analysis was performed to obtain parameters of conventional echocardiography, left atrial and left ventricle strain, and IVP.