Heart Failure With Preserved Ejection Fraction Clinical Trials

59 recruiting

Heart Failure With Preserved Ejection Fraction Trials at a Glance

81 actively recruiting trials for heart failure with preserved ejection fraction are listed on ClinicalTrialsFinder across 6 cities in 45 countries. The largest study group is Not Applicable with 28 trials, with the heaviest enrollment activity in Boston, Dallas, and Rochester. Lead sponsors running heart failure with preserved ejection fraction studies include Mayo Clinic, Northwestern University, and University of Leicester.

Browse heart failure with preserved ejection fraction trials by phase

Treatments under study

About Heart Failure With Preserved Ejection Fraction Clinical Trials

Looking for clinical trials for Heart Failure With Preserved Ejection Fraction? There are currently 59 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Heart Failure With Preserved Ejection Fraction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Heart Failure With Preserved Ejection Fraction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 81 trials

Recruiting

Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction

Type 2 DiabetesHeart Failure With Preserved Ejection Fraction
University of Leicester60 enrolled1 locationNCT06652763
Recruiting
Not Applicable

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection FractionConcentric Hypertrophy
Medtronic Cardiac Rhythm and Heart Failure105 enrolled8 locationsNCT05839730
Recruiting
Phase 3

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

ObesityHeart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection Fraction
Amgen5,056 enrolled596 locationsNCT07037459
Recruiting
Phase 2

A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure

Heart Failure With Preserved Ejection Fraction
Mayo Clinic35 enrolled1 locationNCT07083011
Recruiting
Phase 1

Novel Approaches for Improving Vascular Function in Veterans With HFpEF

InflammationHeart Failure With Preserved Ejection Fraction
VA Office of Research and Development90 enrolled1 locationNCT06312748
Recruiting

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction
Mayo Clinic400 enrolled1 locationNCT07401771
Recruiting
Phase 2

SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

Heart Failure With Preserved Ejection Fraction
University of Pennsylvania53 enrolled1 locationNCT05138575
Recruiting

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

Heart FailureHeart Failure With Preserved Ejection Fraction
Northwestern University1,000 enrolled6 locationsNCT05873634
Recruiting

Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

Heart FailureHeart Failure With Preserved Ejection Fraction
Northwestern University180 enrolled6 locationsNCT06517186
Recruiting
Phase 1Phase 2

Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease

Heart FailureChronic Kidney DiseasesKidney Diseases+1 more
Northwestern University60 enrolled1 locationNCT05719714
Recruiting
Early Phase 1

SGLT2 Inhibitors, Ketones, and Cardiovascular Benefit Research Plan

Heart Failure With Preserved Ejection FractionType2 Diabetes
The University of Texas Health Science Center at San Antonio30 enrolled1 locationNCT05057806
Recruiting
Not Applicable

ELEVATE-HFpEF Clinical Study

Heart Failure With Preserved Ejection Fraction (HFpEF)
Medtronic Cardiac Rhythm and Heart Failure700 enrolled34 locationsNCT06678841
Recruiting
Phase 2

A Study of TX000045 in Patients With Pulmonary Hypertension Secondary to Heart Failure With Preserved Ejection Fraction (the APEX Study)

Pulmonary HypertensionHeart Failure With Preserved Ejection Fraction
Tectonic Therapeutic180 enrolled86 locationsNCT06616974
Recruiting

PBMC as Biomarkers of Diabetic Cardiomyopathy

Metabolic SyndromeType 2 DiabetesHeart Failure With Preserved Ejection Fraction+1 more
Hospices Civils de Lyon175 enrolled1 locationNCT05651919
Recruiting

Purinergic Signaling and the Postmenopausal Heart

Heart Failure With Preserved Ejection FractionDiastolic Heart Failure
Beth Israel Deaconess Medical Center500 enrolled1 locationNCT06015776
Recruiting

Prospective Evaluation of AI-ECG for SHD Detection

Heart Failure With Preserved Ejection Fraction (HFpEF; Diagnosis)Valvular Heart Disease Stenosis and Regurgitation (Diagnosis)Pulmonary Hypertension (Diagnosis)+1 more
Imperial College London590 enrolled5 locationsNCT07057466
Recruiting

Real-Time Monitoring of Heart Failure Across the Yale New Haven Health System

Heart FailureHeart Failure With Reduced Ejection FractionHeart Failure NYHA Class IV+1 more
Yale University40,000 enrolled1 locationNCT04237701
Recruiting

A Study Of CS Reducer For Symptomatic Heart Failure With HFpEF And CMD

Coronary Microvascular DysfunctionHeart Failure With Preserved Ejection Fraction
Mayo Clinic25 enrolled1 locationNCT07093528
Recruiting
Phase 4

Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF)

Iron-deficiencyHeart Failure With Preserved Ejection Fraction
Massachusetts General Hospital66 enrolled1 locationNCT04945707
Recruiting
Not Applicable

Can Tiny Bubbles Offer an Alternative to Catheters for Assessing Pressures Inside the Heart? Investigating Ultrasound Contrast Agents as Pressure Sensors Against Gold Standard Catheter Pressures in Cardiac Catheterisation Patients.

Heart DiseaseHFpEF - Heart Failure With Preserved Ejection FractionCardiac Catheterisation
King's College London10 enrolled1 locationNCT07416279