Heart Failure With Preserved Ejection Fraction Clinical Trials

106 recruitingLast updated: June 18, 2026

There are 106 actively recruiting heart failure with preserved ejection fraction clinical trials across 45 countries. Studies span Not Applicable, Phase 2, Phase 1, Phase 4, Phase 3, Early Phase 1. Top locations include Dallas, Texas, United States, Boston, Massachusetts, United States, Chicago, Illinois, United States. Updated daily from ClinicalTrials.gov.


Heart Failure With Preserved Ejection Fraction Trials at a Glance

106 actively recruiting trials for heart failure with preserved ejection fraction are listed on ClinicalTrialsFinder across 6 cities in 45 countries. The largest study group is Not Applicable with 35 trials, with the heaviest enrollment activity in Dallas, Boston, and Chicago. Lead sponsors running heart failure with preserved ejection fraction studies include Mayo Clinic, University of Leicester, and Northwestern University.

Browse heart failure with preserved ejection fraction trials by phase

Treatments under study

About Heart Failure With Preserved Ejection Fraction Clinical Trials

Looking for clinical trials for Heart Failure With Preserved Ejection Fraction? There are currently 66 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Heart Failure With Preserved Ejection Fraction trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Heart Failure With Preserved Ejection Fraction clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 106 trials

Recruiting
Early Phase 1

Hearts on Fire: Targeting Inflammation in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction (HFpEF)
University of Florida70 enrolled1 locationNCT07634640
Recruiting
Phase 2

Matching Perfusion and Metabolic Activity in HFpEF

Heart Failure With Preserved Ejection Fraction
University of Pennsylvania53 enrolled1 locationNCT04913805
Recruiting
Not Applicable

ELEVATE-HFpEF Clinical Study

Heart Failure With Preserved Ejection Fraction (HFpEF)
Medtronic Cardiac Rhythm and Heart Failure700 enrolled44 locationsNCT06678841
Recruiting

AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

Heart FailureCardiotoxicityMyocardial Infarction+12 more
Peerbridge Health, Inc2,000 enrolled8 locationsNCT06699056
Recruiting
Phase 2

AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

Symptomatic Heart Failure With Preserved Ejection Fraction (HFpEF)
Cytokinetics60 enrolled25 locationsNCT06793371
Recruiting
Phase 3

Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

ObesityHeart Failure With Preserved Ejection FractionHeart Failure With Mildly Reduced Ejection Fraction
Amgen5,056 enrolled605 locationsNCT07037459
Recruiting
Not Applicable

BOOST: Blended Onsite and Offsite Structured Exercise Training and Coaching

Heart Failure With Preserved Ejection Fraction
Wake Forest University Health Sciences14 enrolled1 locationNCT07413198
Recruiting
Phase 2

A Phase II Clinical Trial of HRS-1893 in the Treatment of Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction
Shandong Suncadia Medicine Co., Ltd.48 enrolled1 locationNCT07269717
Recruiting
Phase 2

CAMEO-FONTAN -Dapagliflozin in the Failing Fontan Circulation

HFpEF - Heart Failure With Preserved Ejection FractionFontan CirculationSingle Ventricle Heart Disease
Mayo Clinic27 enrolled1 locationNCT06762964
Recruiting
Not Applicable

Assessment of CCM in HF With Higher Ejection Fraction

Heart FailureHeart Failure With Preserved Ejection FractionDiastolic Heart Failure+2 more
Impulse Dynamics1,500 enrolled105 locationsNCT05064709
Recruiting
Not Applicable

Targeting Breathing Limitations to Improve Functional Outcomes in HFpEF

ObesityHeart Failure With Preserved Ejection Fraction
University of Texas Southwestern Medical Center78 enrolled1 locationNCT05723679
Recruiting

The Role of Epicardial Adiposity in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction (HFpEF)
University of Leicester130 enrolled1 locationNCT06768437
Recruiting

Manganese-enhanced Magnetic Resonance Imaging (MEMRI) in Heart Failure With Preserved Ejection Fraction

Type 2 DiabetesHeart Failure With Preserved Ejection Fraction
University of Leicester60 enrolled1 locationNCT06652763
Recruiting
Phase 2

Coronary Artery Stents in Heart Failure With Preserved Ejection Fraction

Coronary Artery DiseaseHeart Failure With Preserved Ejection Fraction (HFpEF)
King's College London350 enrolled1 locationNCT07560436
Recruiting
Not Applicable

Fast Induced Remodeling in Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection FractionConcentric Hypertrophy
Medtronic Cardiac Rhythm and Heart Failure105 enrolled8 locationsNCT05839730
Recruiting
Phase 2

A Study of 68Ga-Fibroblast Activation Protein Inhibitor (FAPI) Positron Emission Tomography in Heart Failure

Heart Failure With Preserved Ejection Fraction
Mayo Clinic35 enrolled1 locationNCT07083011
Recruiting
Phase 1

Novel Approaches for Improving Vascular Function in Veterans With HFpEF

InflammationHeart Failure With Preserved Ejection Fraction
VA Office of Research and Development90 enrolled1 locationNCT06312748
Recruiting
Phase 2

SGLT2i and KNO3 in HFpEF - The SAK HFpEF Trial

Heart Failure With Preserved Ejection Fraction
University of Pennsylvania53 enrolled1 locationNCT05138575
Recruiting

Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

Heart Failure With Preserved Ejection Fraction
Mayo Clinic400 enrolled1 locationNCT07401771
Recruiting

HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

Heart FailureHeart Failure With Preserved Ejection Fraction
Northwestern University1,000 enrolled6 locationsNCT05873634