RecruitingNot ApplicableNCT06197685

A Novel Combinatory Approach to Maximize Functional Recovery of Learning and Memory in Multiple Sclerosis


Sponsor

Kessler Foundation

Enrollment

78 participants

Start Date

Feb 12, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The goal of this novel study is to compare the effect of a combined cognitive rehabilitation and exercise approach on new learning and memory (NLM) in persons with multiple sclerosis (pwMS) and mobility disability.


Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study tests a combined program of exercise and brain stimulation (transcranial magnetic stimulation) to improve mobility and physical function in people with multiple sclerosis (MS) who are physically inactive and have mild-to-moderate disability. **You may be eligible if...** - You are 18–70 years old - You have a confirmed MS diagnosis from a neurologist - You have mild-to-moderate difficulty with mobility - You are currently physically inactive - You are right-handed - You have been free of relapses and steroid treatment for at least 30 days - English is your primary language **You may NOT be eligible if...** - You have neurological conditions other than MS - You have had a relapse or used steroids within the past 30 days - You are already physically active - You are left-handed Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALThe Kessler Foundation modified Story Memory Technique® (KF-mSMT®)

KF-mSMT is a memory retraining technique that consists of two-related skills: (1) imagery and (2) context/organization. The proposed KF-mSMT intervention includes 10 total sessions with 2 sessions per week for 5 weeks. Each session will last 45-60 minutes.

BEHAVIORALAerobic Exercise Training (AET) plus Virtual Reality (IDEAL)

The AET condition includes 12 weeks of supervised, progressive, moderate intensity cycle ergometry. The AET will include semi-immersive, interactive VR such the cycling speed on the bike will translate directly to perceived speed through the virtual environment.

BEHAVIORALStretching and Toning (S/T)

The S/T condition will include 12 weeks of supervised S/T activities that target the head/neck. shoulder, elbow/forearm, hand/wrist, trunk/hip, ankle/foot.


Locations(1)

Kessler Foundation

East Hanover, New Jersey, United States

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NCT06197685


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