RecruitingNCT06203327

Atrophic Gastritis Predicts the Risk of Gastric Cancer

Atrophic Gastritis Predicts the Risk of Gastric Cancer: a Prospective Cohort Study

Sponsor

Shanghai Jiao Tong University School of Medicine

Enrollment

2,042 participants

Start Date

Dec 15, 2023

Study Type

OBSERVATIONAL

Conditions

Atrophic Gastritis

Summary

Despite declining incidence rates, gastric cancer (GC) ranks the fourth leading cause of cancer-related mortality and the fifth most common cancer worldwide, with the highest incidence reported in Eastern Asia. The 5-year overall survival rate of early GC exceeds 90%, which was well above advanced GC. Most intestinal-type GCs follow the Correa cascade-inflammation,atrophy, intestinal metaplasia (IM), dysplasia and subsequent carcinoma. The presence of gastric mucosal atrophy and intestinal metaplasia are important risk factors for GC. The purpose of this study was to investigate the incidence of GC attributed to atrophic gastritis in a region with high incidence of GC.

Eligibility

Min Age: 18 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This study looks at whether a condition called atrophic gastritis (a type of chronic stomach inflammation that causes thinning of the stomach lining) can predict the future risk of developing stomach cancer, based on biopsy results. **You may be eligible if...** - You are between 18 and 80 years old - You are willing to participate and provide consent - You have had stomach biopsies taken during endoscopy (camera test of the stomach) **You may NOT be eligible if...** - You are under 18 or over 80 years old - You have previously had part or all of your stomach surgically removed - You have serious systemic disease or a known cancer Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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