Atrophic Gastritis Predicts the Risk of Gastric Cancer
Atrophic Gastritis Predicts the Risk of Gastric Cancer: a Prospective Cohort Study
Shanghai Jiao Tong University School of Medicine
2,042 participants
Dec 15, 2023
OBSERVATIONAL
Conditions
Summary
Despite declining incidence rates, gastric cancer (GC) ranks the fourth leading cause of cancer-related mortality and the fifth most common cancer worldwide, with the highest incidence reported in Eastern Asia. The 5-year overall survival rate of early GC exceeds 90%, which was well above advanced GC. Most intestinal-type GCs follow the Correa cascade-inflammation,atrophy, intestinal metaplasia (IM), dysplasia and subsequent carcinoma. The presence of gastric mucosal atrophy and intestinal metaplasia are important risk factors for GC. The purpose of this study was to investigate the incidence of GC attributed to atrophic gastritis in a region with high incidence of GC.
Eligibility
Inclusion Criteria2
- Ability and willingness to participate in the study and to sign and give informed consent
- Biopsies were collected based on the recommendation of updated Sydney system
Exclusion Criteria3
- under 18 or over 80 years old
- history of gastrectomy
- severe systemic diseases or malignancy
Interventions
Surveillance endoscopies at years 3-5.
Surveillance endoscopies at years 2-3.
Surveillance endoscopies every year.
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06203327