Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)

This trial (REPAIR) tests whether low-dose colchicine — an anti-inflammatory medication used for gout — can reduce heart disease risk in people with advanced chronic kidney disease (CKD) or those already on dialysis, who have very high rates of heart attacks and strokes. **You may be eligible if...** - You have advanced chronic kidney disease (estimated kidney function of 30 mL/min or below) but are not yet on dialysis, OR you have been on regular dialysis for at least 90 days - You are 18 or older - You are willing to give informed consent **You may NOT be eligible if...** - You currently take colchicine and cannot stop it for medical reasons - You have a known allergy to colchicine or previously could not tolerate it at low doses - You are pregnant, planning to become pregnant, or breastfeeding - You have a condition that would make colchicine unsafe Talk to your doctor to see if this trial is right for you.