Bronchoscopic Levofloxacin, Gentamicin, or Sham for Acute Exacerbation of Bronchiectasis
A Randomized Sham-Controlled Trial of Bronchoscopic Levofloxacin and Gentamicin Versus Sham in Mechanically Ventilated Bronchiectasis: Acute and 1-Year Outcomes
Assiut University
315 participants
Oct 15, 2023
INTERVENTIONAL
Conditions
Summary
Randomized single-center trial evaluating whether bronchoscopic instillation of levofloxacin or gentamicin improves outcomes compared to a sham bronchoscopic procedure in adult ICU patients with non-cystic fibrosis bronchiectasis requiring invasive mechanical ventilation. The primary outcome is a ranked composite of in-hospital mortality and time to ventilator liberation. Safety and procedural adverse events are closely monitored.
Eligibility
Plain Language Summary
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Interventions
Bronchoscopic local instillation of gentamicin and Budesonide
Bronchoscopic local instillation of Levofloxacin and Budesonide
Bronchoscopic mechanical secretion suction and lavage
Bronchoscopy for airway visualization only, no lavage or drug instillation (sham procedure).
Locations(1)
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NCT06209047