RecruitingNCT06625944

Exploring How Viral Infections Affect People With Chronic Lung Disease

Prospective Cohort Study to Understand Impact of Viral Infection in Chronic Lung Disease

Sponsor

Imperial College London

Enrollment

180 participants

Start Date

Nov 1, 2024

Study Type

OBSERVATIONAL

Conditions

COPD, Chronic Obstructive Pulmonary Disease Bronchiectasis with Acute Exacerbation Bronchiectasis Adult Respiratory Infection Virus

Summary

Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volunteers\' progress for up to two years. Whenever they get unwell they will take some samples (nose swabs, finger prick testing, phlegm sample) and post them to the researchers. Then, they will come in for a visit for more samples (blood tests, further swabs) and a review.

Eligibility

Min Age: 18 Years

Inclusion Criteria3

Adults with a physician confirmed diagnosis of chronic airway disease (e.g. COPD and bronchiectasis) according to established diagnostic criteria.
AND
\- Prior history of exacerbation within last year (defined as requiring antibiotic and/or corticosteroids).

Exclusion Criteria3

Inability to complete daily symptom diaries and/or attend for clinical assessments.
Exacerbation within 4 weeks of study recruitment and/or clinical instability at the time of recruitment.
Pregnancy.