RecruitingNCT06625944

Exploring How Viral Infections Affect People With Chronic Lung Disease

Prospective Cohort Study to Understand Impact of Viral Infection in Chronic Lung Disease

Sponsor

Imperial College London

Enrollment

180 participants

Start Date

Nov 1, 2024

Study Type

OBSERVATIONAL

Conditions

COPD, Chronic Obstructive Pulmonary Disease Bronchiectasis with Acute Exacerbation Bronchiectasis Adult Respiratory Infection Virus

Summary

Many people with chronic lung disease have disease flare-ups. It was previously believed that these were mainly caused by bacteria but recent evidence suggests that viruses could be an important trigger. This study will recruit volunteers with chronic lung disease and take samples both when well (at baseline) and during flare-ups (exacerbations) to better understand the role of viruses in triggering exacerbations and also how the immune response is affected. The researchers will follow the volunteers\' progress for up to two years. Whenever they get unwell they will take some samples (nose swabs, finger prick testing, phlegm sample) and post them to the researchers. Then, they will come in for a visit for more samples (blood tests, further swabs) and a review.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study follows adults with chronic lung conditions like COPD or bronchiectasis to understand how viral infections (such as colds or flu) trigger flare-ups. Participants track daily symptoms and attend clinic visits to help researchers find better ways to predict and prevent these episodes. **You may be eligible if...** - You are an adult with a doctor-confirmed diagnosis of a chronic airway disease such as COPD or bronchiectasis - You have had at least one flare-up in the past year that required antibiotics or steroids **You may NOT be eligible if...** - You are unable to complete daily symptom diaries or attend clinic appointments - You are currently in a flare-up or are medically unstable - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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