Smoldering Myeloma High-Risk Patient Observation and Longitudinal Insight Trial

This is an observational study (not a treatment trial) for people with high-risk smoldering multiple myeloma — a precursor condition to multiple myeloma (a type of blood cancer) that has not yet caused symptoms or organ damage. Researchers want to learn more about how this condition progresses over time by carefully following patients and collecting data. **You may be eligible if...** - You are 18 or older - You have been diagnosed with smoldering multiple myeloma (a pre-cancer blood condition) according to established medical criteria - Your condition is classified as high-risk based on specific markers in your blood and bone marrow - Your high-risk diagnosis was made within the past 12 months - You are willing to participate in long-term follow-up visits **You may NOT be eligible if...** - Your condition has already progressed to active multiple myeloma (with symptoms or organ damage) - You have plasma cell tumors outside the bone marrow - You have any focal bone lesions or areas of bone destruction on imaging - You have already started treatment for multiple myeloma Talk to your doctor to see if this trial is right for you.