A Clinical Study of T3011 in Combination With PD-1/PD-L1 Inhibitors in Subjects With Advanced Solid Tumors

Exclusion Criteria13

• Subjects who have received other antitumor therapy within the prescribed time prior to the first dose;
• Subjects with a history of other malignancies within the prescribed time prior to the start of study treatment.
• At screening, subjects with a history or evidence of high risk cardiovascular disease;
• Subjects with persistent or active infection requiring intravenous anti-infective therapy;
• Subjects with autoimmune diseases or a history of autoimmune diseases;
• Subjects with known psychiatric disorders that may affect trial compliance;
• Subjects who have pleural effusion, pericardial effusion, or ascites before starting treatment and require puncture drainage, or who had received puncture drainage within the specified time before starting the study treatment;
• Subjects requiring systemic treatment with anti-HSV drugs during the study period;
• Subjects who have received live or attenuated vaccines within the prescribed time prior to the first dose, or who plan to receive such vaccines during the study period; Subjects who have received any tumor vaccine in the past;
• Subjects who had undergone major surgery within the prescribed time before the first dose，and had not recovered from surgery-related adverse reactions or were still in the postoperative recovery period，or who plan to undergo major surgery during the study period;
• Subjects with a history of drug use，drug abuse or alcohol abuse within the year prior to signing the ICF;
• Female subjects who are pregnant or breastfeeding, or planning to conceive or have children during the study period;
• The investigator considers it inappropriate to participate in this study.