RecruitingNot ApplicableNCT06214611

Prospective Validation of Adaptive Radiotherapy (ART) in Patients With Head and Neck Tumors

Adaptive Radiotherapy in the Treatment of Patients With a Histologically Confirmed Malignant Tumor in the Head and Neck Region: Prospective Validation of ART in Patients With HNT (Prospektive Validierung Der ART Bei Patientinnen Und Patienen Mit Kopf-Hals Tumoren,)

Sponsor

University Hospital, Essen

Enrollment

50 participants

Start Date

Nov 15, 2023

Study Type

INTERVENTIONAL

Conditions

Radiation Head and Neck Cancer Adaptive Radiotherapy Optimized Treatment Protection of Organs at Risk Dysphagia Reduction

Summary

Adaptive radiotherapy (ART) includes image-guided radiotherapy (IGRT) and also offers further possibilities for plan adaptation. A particularly high benefit can be expected for patients in whom the clinical target volume (CTV) can show a significant change in shape from fraction to fraction due to anatomical deviations. The shape and position constancy of the CTV during the course of the series is examined in this trial. Dosimetric disadvantages of this type have not been reported so far. The aim of this study is to identify patients who benefit from ART at an early stage and to select them for this method, and then to continue to offer ART to this patient group. If a relevant reduction in the minimum planning target volume (PTV) margins with ART compared to IGRT is demonstrated in this study, patients could be treated with ART.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This trial is validating a technique called adaptive radiotherapy (ART) for head and neck cancer patients. Traditional radiation uses the same plan for every session, but adaptive radiotherapy adjusts the treatment plan during the course of treatment to account for changes in tumor size and patient anatomy. This study aims to confirm that this personalized approach works well in practice. **You may be eligible if...** - You have a tumor in the head or neck region - Your cancer has been confirmed by tissue biopsy - You have been recommended to receive radiation therapy - You are in good physical health (ECOG performance status 0 or 1) - You are willing and able to comply with the treatment and follow-up schedule **You may NOT be eligible if...** - You are pregnant Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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