RecruitingNCT06215274

Cognitive Leisure and Preclinical Alzheimer's Disease: Exploring Neural Mechanisms

The Impact of Cognitive Leisure Activity Levels on Cognitive Function in the Preclinical Stage of Alzheimer's Disease and the Study of Its Neural Circuitry Regulation Mechanisms


Sponsor

Yuanjiao Yan

Enrollment

156 participants

Start Date

Apr 27, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

The goal of this clinical trial is aims to: 1. Translate and culturally adapt the Cognitive Leisure Activity Scale (CLAS) into Chinese and Conduct reliability and validity tests for the Chinese version of CLAS. 2. Investigate the correlation between cognitive leisure activity levels and cognitive function in the preclinical stage of Alzheimer's Disease (AD). 3. Clarify the regulatory mechanisms of cognitive leisure activity levels on the neural circuits of patients in the preclinical stage of AD.


Eligibility

Min Age: 60 Years

Plain Language Summary

Simplified for easier understanding

This study is investigating whether mentally stimulating leisure activities — such as reading, puzzles, or learning new skills — can protect brain function in older adults who are in the early stages of cognitive decline that may be related to Alzheimer's disease. Researchers will use brain scans (MRI) to understand how these activities affect neural circuits involved in memory and thinking. **You may be eligible if...** - You are 60 years old or older - You have been diagnosed with mild cognitive impairment (MCI) or subjective cognitive decline (SCD — meaning you feel your memory or thinking has worsened, even if tests are still normal) - You can communicate in Mandarin - You have basic comprehension and judgment ability **You may NOT be eligible if...** - You have severe hearing or speech problems that prevent participation - You have serious physical illness that prevents cooperation with the study - You have a pacemaker, metal implants, cochlear implants, claustrophobia, or other reasons you cannot undergo an MRI scan Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERRelationship of the cognitive leisure activity levels, cognitive function, and MRI characteristics.

The cognitive leisure activity levels, cognitive function, and MRI characteristics in people in the preclinical stage of Alzheimer's Disease (AD).


Locations(1)

Fujian Provincial Hospital

Fuzhou, Fujian, China

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NCT06215274


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