RecruitingNot ApplicableNCT06217276

Respiratory Muscle Fatigue and Lower Extremity Muscle Oxygenation

Examining the Relationship Between Respiratory Muscle Fatigue and Lower Extremity Muscle Oxygenation in Chronic Obstructive Pulmonary Disease Patients.

Sponsor

Istanbul Medipol University Hospital

Enrollment

30 participants

Start Date

Jan 20, 2024

Study Type

INTERVENTIONAL

Conditions

COPD

Summary

In our study, changes in vastus lateralis muscle oxygenation will be evaluated with the Moxy device, a functional infrared oxygen measurement device, during the inspiratory muscle fatigue protocol in COPD cases and the healthy control group.

Eligibility

Min Age: 18 YearsMax Age: 75 Years

Inclusion Criteria5

Having a diagnosis of Stage 2-3 COPD according to the following clinical diagnostic criteria according to the American Thoracic and European Respiratory Societies (ATS-ERS).
Having been using the same medications for the last 4 weeks
Being over 18 years of age
Not having any diagnosed chronic disease
Not being a smoker

Exclusion Criteria7

Patients with severe comorbid diseases, unstable coronary artery disease, collagen vascular diseases and requiring high-flow oxygen therapy (˃ 3-4 L\\min).
Presence of any vascular problem that may affect lower extremity muscle oxygenation
Presence of another respiratory system disease other than COPD
Patients who have had an acute COPD exacerbation in the last 4 weeks
Patients experiencing COPD exacerbations during the study protocol
Presence of fatty tissue or scar tissue at the measurement points, which may impair the measurement quality.
Have already participated in another clinical trial within the last 30 days that may affect the results of the study.

Interventions

OTHERRespiratory muscle fatigue protocol

It will be performed using a powerbreath device at 60% of the maximum inspiratory pressure (MIP) amount obtained by measuring mouth pressure. The protocol includes 7 sets consisting of 2 minutes of inspiratory effort and 1 minute of rest. To further confirm the occurrence of fatigue, the patient will score fatigue using the modified Borg scale, and the score will be 5 or above11. During the application, heart rate, blood pressure and peripheral oxygen saturation will be monitored. The measurement will be performed once for each case.