TRAIL Study: Feasibility and Pilot

This pilot feasibility study is evaluating a new approach to monitoring thyroid nodules — small lumps in the thyroid gland — using active surveillance (watchful waiting with regular imaging) instead of immediate biopsy. The study aims to assess whether this monitoring-first approach is safe and acceptable to patients and providers for nodules that are suspicious but small. **You may be eligible if...** - You are 18 or older with a thyroid nodule rated TI-RADS 4 or 5 (intermediate to high suspicion) - Your nodule is 2 cm or smaller - You are being considered for a biopsy - You do not have symptoms from the nodule (no trouble swallowing, no visible lump bothering you) - You may have a prior history of papillary thyroid cancer **You may NOT be eligible if...** - Your nodule is invading the airway or surrounding structures - Your nodule has spread to nearby lymph nodes or elsewhere - You have had radiation to the neck area - Your thyroid has been removed or you only have thyroid tissue at the base of your tongue - You have had a biopsy of this specific nodule already - You have a history of any thyroid cancer other than papillary thyroid cancer Talk to your doctor to see if this trial is right for you.