Thyroid Nodule Clinical Trials

38 recruitingLast updated: June 18, 2026

There are 38 actively recruiting thyroid nodule clinical trials across 14 countries. Studies span Not Applicable, Phase 4. Top locations include New York, New York, United States, Guangzhou, Guangdong, China, Beijing, Beijing Municipality, China. Updated daily from ClinicalTrials.gov.


Thyroid Nodule Trials at a Glance

38 actively recruiting trials for thyroid nodule are listed on ClinicalTrialsFinder across 6 cities in 14 countries. The largest study group is Not Applicable with 18 trials, with the heaviest enrollment activity in New York, Guangzhou, and Beijing. Lead sponsors running thyroid nodule studies include Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Chinese PLA General Hospital, and Columbia University.

Browse thyroid nodule trials by phase

Treatments under study

About Thyroid Nodule Clinical Trials

Looking for clinical trials for Thyroid Nodule? There are currently 23 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Thyroid Nodule trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Thyroid Nodule clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 38 trials

Recruiting

Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

Thyroid NodulesPulsed Field Ablation
M.D. Anderson Cancer Center30 enrolled1 locationNCT07226804
Recruiting

RFA of Benign Thyroid Nodules: Clinical Outcomes and Quality of Life Study

Thyroid Nodules
Columbia University100 enrolled1 locationNCT05189314
Recruiting

Radiofrequency Ablation for BIII Thyroid Nodules

Indeterminate Bethesda III Thyroid Nodules
Columbia University50 enrolled1 locationNCT05189808
Recruiting

Surgical Competency for Robot-Assisted Thyroidectomy: Construction and Validation of a Robotic Thyroidectomy Assessment Score (RTAS)

Thyroid CancerThyroid Cancer, PapillaryThyroid Diseases+2 more
Shanghai 6th People's Hospital200 enrolled1 locationNCT06730321
Recruiting

Renovated Prediction Model for Difficult Transoral and Submental Endoscopic Thyroidectomy

Thyroid CancerThyroid DiseasesThyroid Nodule
Shanghai 6th People's Hospital300 enrolled1 locationNCT06738888
Recruiting

Percutaneous Thermo-ablation for the Treatment of Benign Thyroid Nodules

Benign Thyroid Nodule
University Hospital, Ghent50 enrolled3 locationsNCT07237373
Recruiting
Not Applicable

Prospective Evaluation of the Pulse Biosciences nPulse™ Vybrance™ Percutaneous Electrode System

AblationThyroid NoduleThyroid Goiter
Pulse Biosciences, Inc.100 enrolled3 locationsNCT07287176
Recruiting

Multimodal Assessment of Malignancy in Atypia of Undetermined Significance in Thyroid Nodules Using Ultrasound and Cytology Whole-Slide Images

Thyroid Nodule
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University396 enrolled1 locationNCT07488325
Recruiting
Not Applicable

TRAIL Study: Feasibility and Pilot

Thyroid CancerThyroid NoduleThyroid Neoplasms
Dartmouth-Hitchcock Medical Center20 enrolled1 locationNCT06220656
Recruiting
Phase 4

Efficacy and Safety of Prunella Oral Liquid in the Treatment of Thyroid Nodules

Thyroid Nodule
Xintian Pharmaceutical234 enrolled22 locationsNCT06423235
Recruiting

CEUS Improves the Diagnostic Performance of SRSS of Thyroid Carcinoma

Thyroid CarcinomaThyroid Nodule
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University800 enrolled1 locationNCT06146764
Recruiting
Not Applicable

The Outcomes of Ultrasound-guided Thermal Ablation for Benign Thyroid Nodules

Thyroid Nodules
Chinese PLA General Hospital1,500 enrolled1 locationNCT06340945
Recruiting

Postoperative Hypocalcemia After Thyroidectomy

Thyroid CancerPostoperative ComplicationsThyroid Nodule+2 more
Minia University600 enrolled1 locationNCT07428057
Recruiting
Not Applicable

Active Surveillance for Bethesda IV Thyroid Nodules

Thyroid CancerThyroid Nodule
Christian Grønhøj Larsen165 enrolled1 locationNCT07370675
Recruiting
Not Applicable

Thyroid Artery Embolization for the Treatment of Compressive Goiters.

Thyroid Nodules
Université de Sherbrooke20 enrolled1 locationNCT07360587
Recruiting
Not Applicable

Thyroid Artery Goitre Embolization Trial A Pilot Study Investigating Thyroid Artery Embolisation as a Treatment for Large Thyroid Nodules

Graves DiseaseThyroid Nodule \(Benign\)Goitre
Royal Berkshire NHS Foundation Trust10 enrolled1 locationNCT07046546
Recruiting
Not Applicable

Efficacy of Lavender Aromatherapy on Anxiety and Pain Reduction During Awake Otolaryngologic Procedures

Thyroid NodulesInferior Turbinate HypertrophyChronic Rhinosinusitis (CRS)+2 more
Cedars-Sinai Medical Center184 enrolled1 locationNCT07299474
Recruiting
Not Applicable

A Study of Multiparametric Ultrasound Imaging Methods

Pancreatic CancerThyroid Nodule
Memorial Sloan Kettering Cancer Center85 enrolled7 locationsNCT07270237
Recruiting
Not Applicable

Decision Aid and Thyroid Nodules Management

Thyroid Nodule
Stony Brook University134 enrolled1 locationNCT05264857
Recruiting
Not Applicable

Radiofrequency Ablation Study in LatinX Patients

Thyroid Nodule
Northwell Health44 enrolled1 locationNCT05903196