Predicting Treatment Outcomes in Refractory Constipation Through Brain Connectivity Evaluation
Evaluation of Brain Connectivity Function in Predicting Therapeutic Effects in Patients With Refractory Constipation: a Multicenter, Prospective, Cohort Study
Xijing Hospital of Digestive Diseases
150 participants
Nov 1, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to identify the characteristics of brain functional connectivity in refractory constipation and fluoxetine-sensitive patients. The main questions it aims to answer are: * Investigating the alterations in brain functional connectivity in patients with refractory constipation and fluoxetine-sensitive patients * Assessing the predictive value of brain functional connectivity regarding the efficacy of fluoxetine and standard protocol treatments for constipation. Participants will receive: * Standard physiological and psychological assessments of constipation * BOLD-fMRI tests * Standard protocol and fluoxetine treatment If there is a comparison group: Researchers will compare: Refractory group/Fluoxetine sensitive group to see the specific brain alterations.
Eligibility
Plain Language Summary
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Interventions
Blood-Oxygen-Level Dependent Functional Magnetic Resonance Imaging
at least 3 months of continuous regular treatment. This treatment included the utilization of osmotic laxatives, stimulant laxatives, prosecretory agents, and a high-fibre diet.
Fluoxetine oral treatment for 4 weeks.
Locations(3)
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NCT06221722