Ketogenic and Nutritional Interventions for First Episode Bipolar Disorder

This study is testing whether dietary changes — specifically a ketogenic (very low carbohydrate, high fat) diet and other nutritional approaches — can improve symptoms and brain health in people who have recently been diagnosed with bipolar disorder or schizoaffective disorder. **You may be eligible if...** - You are between 18 and 45 years old - You have been diagnosed with bipolar I disorder or schizoaffective disorder in the last 7 years - Your psychiatric condition is currently stable and your medications have not changed in the past 2 weeks - You are able and willing to follow the study diet for 12 weeks **You may NOT be eligible if...** - You are pregnant, nursing, or not using contraception - You have type 1 or type 2 diabetes - You currently have a substance use disorder - Your BMI is under 20 or you weigh over 350 pounds - You have an unstable medical condition (heart, liver, kidney, lung, or neurological disease) - You have had gastric bypass or weight loss surgery - You have a condition called familial hypercholesterolemia (very high inherited cholesterol) - You currently have cancer Talk to your doctor to see if this trial is right for you.