A Multi Tumor, Open Phase I Clinical Study on the Progression of First-line Anti-tumor Therapy Using Cardonizumab Combined With Pulsed Low-dose Rate External Irradiation (PLDR)

This trial is testing a combination of an immunotherapy drug (cardonizumab) with a special type of low-dose radiation therapy for people with certain advanced cancers — specifically esophageal cancer, lung cancer, or cervical cancer — that has come back or spread after previous treatment. **You may be eligible if...** - You are 18 to 75 years old - You have been diagnosed with esophageal cancer, lung cancer, or cervical cancer - Your cancer has come back or spread after prior treatment - You are able to carry out basic daily activities - Your blood counts, liver, and kidney values are within acceptable ranges - Your heart is functioning normally **You may NOT be eligible if...** - You have had a stroke, blood clot, or serious heart problem in the last 6 months - You have an active infection or severe uncontrolled illness - You are pregnant or breastfeeding - You are taking other cancer treatments at the same time - You have a history of organ transplant or immune system disease Talk to your doctor to see if this trial is right for you.