RecruitingNCT06236464

Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas

Identification of the Pathogenetic Mechanisms Underlying Squamous Cell Carcinomas of the Anogenital Tract and of the Head-neck Region for the Development of Shared Therapeutic Strategies

Sponsor

National Cancer Institute, Naples

Enrollment

170 participants

Start Date

Sep 25, 2023

Study Type

OBSERVATIONAL

Conditions

Squamous Cell Carcinoma of the Head and Neck Squamous Cell Carcinoma of the Anus

Summary

This is a multicentric, retrospective, and prospective biomarker study.

Eligibility

Min Age: 18 Years

Inclusion Criteria1

Patients aged ≥ 18 years, candidates for surgical treatment for squamous cell carcinoma of the anus, uterine cervix, vulva, and head-neck region (including microinvasive and invasive carcinomas) who are capable of understanding and willing to sign the informed consent form. Prospective patients must provide written informed consent before any procedures.

Exclusion Criteria3

Metastatic neoplasia
Treatment for other oncological pathologies
Congenital or acquired immunosuppression (HIV, organ transplant, pharmacological)

Interventions

OTHERMultiparameter analysis of each sample

Retrospective and prospective samples will be collected and analyzed for the study of molecular and viral biomarkers. Simultaneously, fibroblastic tumor-associated cells (CAFs) will be isolated from prospective samples. Through co-cultivation with immortalized cell lines derived from anogenital and head-neck SCCs, these CAFs will enable the production of 3D organoids for use in experiments assessing the response to telomerase and deacetylase SIRT1 inhibitors, both in vitro and in preclinical models.