Remifentanil Effect on Burst Suppression Ratio
Influence of Variable Plasma Concentrations of Remifentanil on Burst Suppression (BS) Event Rate in Electroencephalographic (EEG) Recordings of Human Subjects Undergoing Total Intravenous General Anesthesia (TIVA) Under Propofol
University of Chile
20 participants
Mar 1, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol in adult patients (18-60 years) candidates for elective surgery who require remifentanil and American Society of Anesthesiology (ASA) classification I or II. The main question it aims to answer are: • To determine whether remifentanil has a facilitating effect on the generation of burst suppression by propofol. Participants will undergo general anesthesia with remifentanil and propofol sequentially. After loss of consciousness, remifentanil will be adjusted to a medium or high concentration randomly and it will be determined at what concentration of propofol the burst suppressions are generated. Then, the concentrations of propofol that generate burst suppression associated with either a medium or high concentration of remifentanil will be compared.
Eligibility
Plain Language Summary
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Interventions
The dose of remifentanil will be changed to determine the concentration of propofol at which burst suppressions are generated
The dose of remifentanil will be changed to determine the concentration of propofol at which burst suppressions are generated
Locations(2)
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NCT06237101