The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients
The Impact of Multiple Antihypertensive Therapy on Post-Induction Hypotension Burden in Cardiac Surgery Patients: A Prospective Observational Cohort Study
Konya City Hospital
160 participants
May 1, 2026
OBSERVATIONAL
Conditions
Summary
This study aims to investigate the impact of multiple preoperative antihyperstensive drug use on the burden of post-induction hypotension (PIH) in patients undergoing elective cardiac surgery. The researchers will observe whether the combination of different antihypertensive classes (such as ACE inhibitors, ARBs, beta-blockers, and calcium channel blockers) leads to a higher incidence and severity of blood pressure drops and increased need for vasoactive support during the period between anesthesia induction and surgical incision.
Eligibility
Inclusion Criteria4
- Adult patients aged 40 years and older
- Undergoing elective cardiac surgery (e.g., isolated CABG, isolated valve surgery, or combined CABG+valve surgery via sternotomy)
- Regular use of at least one antihypertensive medication for at least 4 weeks prior to the operation date
- Voluntary participation and signed informed consent
Exclusion Criteria6
- Emergency surgery
- Preoperative shock or requirement for high-dose inotropic/vasopressor therapy
- End-stage liver or kidney failure
- Uncontrolled hypertension
- Difficult intubation or prolonged induction process
- Ejection fraction less than 35%
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Interventions
Patients' chronic antihypertensive drug use (number of drugs and pharmacological classes) will be recorded. This is an observational study where existing medication regimens (ACE inhibitors, ARBs, Beta-blockers, Calcium Channel Blockers, Diuretics) are documented to analyze their impact on the post-induction hypotension burden (MAP \< 55 mmHg).
Locations(1)
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NCT07541222