Effects of Goji vs. Fiber on Macular Degeneration
Effects of Goji Berry Intake on Risk of Age-related Macular Degeneration: A Randomized Clinical Trial
University of California, Davis
60 participants
Apr 29, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this project is to conduct a clinical trial in 60 participants ranging from age 65-95 who are at risk for age-related macular degeneration (AMD). The study will evaluate the effects of 14g of goji berry intake or an equivalent amount and type of fiber, five days a week for six months, on visual health, gut microbiome profiles, skin carotenoid measures, and lipoprotein profiles.
Eligibility
Inclusion Criteria3
- Family history of AMD
- Hyperlipidemia or managed diabetes
- - 95 years of age
Exclusion Criteria13
- Dislike of, or allergy to, goji berries or any of the ingredients in the fiber-rich wafers and gummies (wheat, corn, oats, soy, natural orange flavor, xylitol, annatto, pectin, or other food ingredients)
- Consumption of > 2 alcoholic drinks per day
- Indications of substance or alcohol abuse
- Current or planned use of a blood thinner (e.g., Coumadin, Warfarin) at any time during study
- Use of multi-vitamin or any other supplements that contain lutein and/or zeaxanthin (if willing to stop the supplement, subject can be enrolled 6 months from stop date)
- Taking any new medications started within the past 6 months, or changes in medication regimen planned in the next 6 months (stable use greater than 6 months is not exclusionary)
- Any planned international travel during the study
- Consuming >3 servings/day of a combination of spinach, kale, lettuce, orange bell peppers, corn, parsley, squash, broccoli, pumpkin, edamame
- Regularly consuming >3 eggs/day
- Currently participating in any other interventional research study
- Diagnosed with inflammatory bowel disease, irritable bowel syndrome, other gastrointestinal disorder, undergoing cancer therapy or immunocompromised, or diagnosis of another condition where lutein, zeaxanthin and/or fiber supplementation would be contraindicated or would interfere with ability to participate in the study
- Any physical characteristic or condition that precludes ability to perform study procedures
- Medical or psychiatric condition that, in the opinion of the Investigator, would compromise study findings or prevent the participant from completing the study
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Interventions
Participants will be instructed to consume 14 grams of goji berries 5 days a week for 6 months
Participants will be instructed to consume the fiber supplements 5 days a week for 6 months
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06237127