Comparative Outcomes Related to Delivery-room Cord Milking In Low-resourced Kountries- PreTerm
A Cluster Randomized Clinical Trial of Umbilical Cord Milking Compared to Early Cord Clamping in Preterm Infants Who Are Non-vigorous at Birth
Nemours Children's Clinic
800 participants
Jul 1, 2024
INTERVENTIONAL
Conditions
Summary
The goal of this multicenter, cluster-randomized, crossover trial is to determine if umbilical cord milking compared to early cord clamping will reduce in-hospital mortality in non-vigorous preterm infants born between 30 weeks and 34 weeks of gestation.
Eligibility
Inclusion Criteria2
- Preterm infants born between 30 0/7 weeks to 34 6/7 weeks of gestation
- Non-vigorous at birth
Exclusion Criteria7
- Infants with congenital malformation
- Major chromosomal abnormalities
- Complete placental abruption/cutting through the placenta at the time of delivery
- Cord conditions (umbilical knots, inadequate cord length, cord rupture, non-reducible nuchal cord)
- Mono-chorionic twins,
- Twins with no information on amnion/chorion
- Multiple gestation \>2
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Interventions
At delivery, the umbilical cord is grasped, and blood is pushed toward the infant 4 times before the cord is clamped. This procedure infuses a placental transfusion of blood into the infant and can be done in 1--15 seconds.
Locations(9)
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NCT06240715