The CardioClip Study

This study is evaluating a minimally invasive heart procedure called transcatheter edge-to-edge repair (mTEER) for people with heart failure caused by a leaky mitral valve (secondary mitral regurgitation). Instead of open-heart surgery, a small clip is used to repair the valve through a catheter — a much less invasive approach. **You may be eligible if...** - You have moderate-severe (3+) or severe (4+) mitral valve leakage caused by heart failure - Your heart's pumping function is reduced (ejection fraction between 20% and 50%) - You have symptoms of heart failure (NYHA class II–IVa) - Your mitral valve anatomy is suitable for the clip procedure **You may NOT be eligible if...** - Your left ventricle is severely enlarged (end-systolic dimension over 70 mm) - Your pulmonary artery pressure is severely elevated and fixed - Your mitral valve opening area is too small (less than 4.0 cm²) - You are likely to need a heart transplant or mechanical heart support device within 12 months - You have a history of recurrent blood clots - You have complex congenital heart disease - You have a mechanical heart valve on the right side - You have a history of not taking medications as prescribed Talk to your doctor to see if this trial is right for you.