Mitral Regurgitation Clinical Trials

49 recruiting

Mitral Regurgitation Trials at a Glance

71 actively recruiting trials for mitral regurgitation are listed on ClinicalTrialsFinder across 6 cities in 34 countries. The largest study group is Not Applicable with 36 trials, with the heaviest enrollment activity in New York, Cleveland, and Bonn. Lead sponsors running mitral regurgitation studies include Abbott Medical Devices, HighLife SAS, and Chinese Academy of Medical Sciences, Fuwai Hospital.

Browse mitral regurgitation trials by phase

Treatments under study

About Mitral Regurgitation Clinical Trials

Looking for clinical trials for Mitral Regurgitation? There are currently 49 studies actively recruiting participants. Clinical trials offer access to new treatments before they are widely available, and every approved therapy in use today was first tested through a clinical trial.

Below you can browse trials, sign up for alerts when new Mitral Regurgitation trials open, and view eligibility criteria for each study. Each listing includes the study phase, locations, and enrollment details.

Frequently Asked Questions

Common questions about Mitral Regurgitation clinical trials

A clinical trial is a carefully designed research study that tests new medical treatments, drugs, devices, or approaches in human volunteers. Every approved medication and treatment available today was proven safe and effective through clinical trials.

All clinical trials are reviewed and approved by Institutional Review Boards (IRBs) — independent committees that evaluate patient safety. Trials follow strict protocols, and your health is monitored closely throughout. You can withdraw at any time.

Not necessarily. Many trials compare the new treatment against the current standard of care, meaning all participants receive active treatment. When placebos are used, they are typically combined with standard treatment, not given alone. The trial description will always specify the design.

Under the Affordable Care Act, most private insurers are required to cover routine patient care costs during a clinical trial. The sponsor typically covers the investigational treatment itself. Medicare also covers routine costs for qualifying trials.

Yes. Participation is completely voluntary. You can withdraw at any time, for any reason, without it affecting your access to standard medical care.

Each trial has specific eligibility criteria — including age, diagnosis, disease stage, prior treatments, and general health. Browse the trials listed above and check their eligibility sections. You can also contact the trial site directly to discuss your situation.

Showing 120 of 71 trials

Recruiting
Not Applicable

A Clinical Study of GeminiOne TEER System for the Treatment of Severe, Symptomatic MR.

Mitral Regurgitation
Sierra Valve LLC15 enrolled1 locationNCT07086534
Recruiting

Atrial Functional Mitral Regurgitation and Tricuspid Regurgitation

Atrial FibrillationFunctional Mitral RegurgitationFunctional Tricuspid Regurgitation
Barts & The London NHS Trust141 enrolled1 locationNCT05920824
Recruiting

DELINEATE-Prospective

Valvular Heart DiseaseValve Disease, AorticAortic Stenosis+2 more
Columbia University50 enrolled1 locationNCT07197736
Recruiting

Novel 3-dimensional Echocardiographic Quantification of Mitral Regurgitant Volume

Moderate or Severe Mitral Regurgitation
Germans Trias i Pujol Hospital200 enrolled1 locationNCT07528781
Recruiting
Not Applicable

The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

Heart FailureCardiovascular DiseasesHeart Diseases+3 more
Cardiac Dimensions, Inc.300 enrolled92 locationsNCT03142152
Recruiting
Not Applicable

Cephea Early Feasibility Study

Mitral Regurgitation
Abbott Medical Devices50 enrolled22 locationsNCT05061004
Recruiting
Not Applicable

Safety and Feasibility Study of the MitraFix® Transcatheter Mitral Valve System

Mitral Regurgitation (MR)
Mitrassist Lifesciences Limited Co., Ltd.5 enrolled1 locationNCT07501234
Recruiting
Not Applicable

Efficacy and Safety of Catheter abLation in patiEnts With seVere mitrAl regurgiTation and pErsistent Atrial Fibrillation: a Randomized Controlled Trial

Atrial Fibrillation (AF)Catheter AblationAtrial Functional Mitral Regurgitation
Beijing Anzhen Hospital146 enrolled17 locationsNCT06883864
Recruiting

Abbott Cephea Mitral Valve Disease Registry

Mitral RegurgitationMitral StenosisMitral Valve Disease+4 more
Abbott Medical Devices1,000 enrolled19 locationsNCT07069673
Recruiting
Phase 4

STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication for Oral Anticoagulant

Mitral Regurgitation
Chinese Academy of Medical Sciences, Fuwai Hospital1,032 enrolled1 locationNCT07007143
Recruiting
Phase 4

STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients With an Indication for Oral Anticoagulant

Mitral Regurgitation
Chinese Academy of Medical Sciences, Fuwai Hospital880 enrolled1 locationNCT06901466
Recruiting
Phase 1

A Clinical Study Evaluating the Replacement of the Native Mitral Valve Using the ReValve System

Mitral Regurgitation
ReValve Solutions Inc.20 enrolled3 locationsNCT07450911
Recruiting
Not Applicable

The ENCIRCLE Trial

Mitral RegurgitationMitral Valve Insufficiency
Edwards Lifesciences900 enrolled68 locationsNCT04153292
Recruiting
Not Applicable

EFS of the CardioMech MVRS

Mitral Regurgitation
CardioMech AS25 enrolled12 locationsNCT04820764
Recruiting
Not Applicable

Cephea South America Feasibility Study

Mitral RegurgitationMitral Stenosis
Abbott Medical Devices20 enrolled3 locationsNCT07244939
Recruiting
Not Applicable

The MITRAL II Pivotal Trial (Mitral Implantation of TRAnscatheter vaLves).

Mitral RegurgitationMitral StenosisMitral Valve Disease+1 more
Mayra Guerrero210 enrolled17 locationsNCT04408430
Recruiting

Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance

Heart Failure and Reduced Ejection FractionFunctional Mitral Regurgitation
Minneapolis Heart Institute Foundation125 enrolled6 locationsNCT07131631
Recruiting
Not Applicable

Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - APOLLO-EU Trial

Mitral Regurgitation
Medtronic Cardiovascular400 enrolled37 locationsNCT05496998
Recruiting

In Search of Best Practices for Patients With Heart Failure and Secondary Mitral Regurgitation: An Evaluation of the Inova Heart Failure Treatment Algorithm

Heart FailureValvular Heart DiseaseMitral Regurgitation
Inova Health Care Services50 enrolled1 locationNCT06675448
Recruiting

3D Ultrasound Myocardial Mechanical Wave Measurements

Chronic Primary Mitral Regurgitation
Assistance Publique - Hôpitaux de Paris40 enrolled2 locationsNCT06648577