Oscillatory Activity in Basal Ganglia Circuits During Normal and Pathological Movement
University Hospital, Bordeaux
30 participants
Feb 5, 2024
INTERVENTIONAL
Conditions
Summary
The expression of hypokinetic and hyperkinetic motor symptoms is accompanied by pathological synchronous oscillations of neuronal activity in this cortico-subcortical network with a wide frequency range. The purpose of this research is to study cortico-subcortical oscillations and their synchronization in two pathologies emblematic of hypokinetic (Parkinson's disease) and hyperkinetic (epilepsies) phenomena using a simple motor task and comparing different situations.
Eligibility
Inclusion Criteria9
- Male or Female
- Between 18 and 75 years of age
- With Parkinson's disease and already operated with implantation of electrodes in the Subthalamic nucleus connected to a PERCEPT (TM) device.
- Giving free, informed, written consent signed by the participant and the investigator Or
- With drug-resistant epilepsy and benefiting from a phase II pre-surgical assessment with intracerebral electrophysiological exploration by stereo-EEG
- With at least one electrode exploring the basal ganglia or the thalamus.
- Able to perform the simple motor task
- Affiliated or beneficiary of a social security scheme;
- Giving free, informed, written consent signed by the participant and the investigator
Exclusion Criteria4
- Be incapable of giving consent personally
- Be subject to a legal protection measure or be placed under judicial protection;
- Being pregnant or breastfeeding
- Present a serious and/or decompensated somatic or psychiatric illness
Interventions
Local field potentials (LFP) recording using EEG-HR
Local field potentials (LFP) recording using sEEG
Locations(1)
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NCT06241924