A Phase I/II Study of AST-001 in Subjects With Advanced Solid Tumors

This early-phase study is testing a new drug called AST-001 in people with advanced solid tumors (cancers that form solid masses) that have spread or cannot be surgically removed and for which standard treatments are no longer working. The initial phase focuses on finding the safest dose, followed by testing effectiveness. **You may be eligible if...** - You are between 18 and 70 years old - You have a confirmed advanced solid tumor for which standard curative treatments no longer exist or are not effective - Your general health is good (ECOG performance status 0 or 1) - Your life expectancy is at least 12 weeks - Your liver, kidneys, and bone marrow are functioning adequately - Side effects from prior cancer treatments have largely resolved **You may NOT be eligible if...** - You have had another primary cancer in the past 2 years (with some exceptions like treated skin cancer) - You have active or untreated brain metastases - You have serious heart problems or uncontrolled infections - You are pregnant or breastfeeding - You have had prior treatment with a similar type of drug Talk to your doctor to see if this trial is right for you.