Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)
Manually Controlled Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section: A Double-blinded Randomized Controlled Study
Hassan II University
140 participants
Jan 29, 2025
INTERVENTIONAL
Conditions
Summary
The goal of this clinical trial is to compare norepinephrine and ephedrine in maintaining blood pressure during spinal anaesthesia for elective cesarean delivery. The main questions it aims to answer are: * Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on neonatal outcome ? * Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on maternal hemodynamics? Participants will receive either phenylephrine or norepinephrine infusion, at the time of performing spinal anesthesia, the infusion rate will be adjusted manually depending on maternal arterial pressure.
Eligibility
Inclusion Criteria4
- Full-term, singleton, pregnant women, nonlaboring.
- Scheduled for elective cesarean delivery under spinal anesthesia,
- American Society of Anesthesiologists physical status : 1 or 2
- Baseline systolic BP between 90 and 140 mm Hg.
Exclusion Criteria5
- Known fetal abnormality.
- Preexisting or pregnancy-induced hypertension, cardiovascular, cerebrovascular or kidney disease.
- Contraindication to spinal anesthesia.
- Peripartum hemorrhage.
- Body mass index above 40 kg/m2.
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Interventions
The rate of norepinephrine infusion will be adjusted according to values of systolic blood pressure measured noninvasively and recorded at 1-minute intervals along the intraoperative period, with the objective of maintaining values near baseline.
The rate of phenylephrine infusion will be adjusted according to values of systolic blood pressure measured noninvasively and recorded at 1-minute intervals along the intraoperative period, with the objective of maintaining values near baseline.
Locations(2)
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NCT06248593