RecruitingNot ApplicableNCT06252129

Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens

Sponsor

Brigham and Women's Hospital

Enrollment

160 participants

Start Date

Jul 26, 2024

Study Type

INTERVENTIONAL

Conditions

Lung Cancer Lymph Node Metastasis Pathologic Processes

Summary

Lung cancer patients undergoing upfront surgery, highly benefit from a systematic lymph node dissection in the mediastinum and in the surgical specimens. The latter is performed by the pathologist. Developing a standardized technique to dissect the lobectomy specimen has the potential of maximizing the retrieval of all N1 stations lymph nodes. The investigators believe that the adoption of such technique will improve lung cancer staging and identify a higher number of patients that qualify for adjuvant therapies.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study looks at the best way to examine lymph nodes removed during lung cancer surgery. Surgeons currently remove part of the lung along with nearby lymph nodes, but the best method for analyzing those nodes (fresh vs. chemically preserved) is not yet standardized. Better lymph node analysis helps doctors stage cancer more accurately and plan treatment. **You may be eligible if...** - You are 18 or older - You have a lung nodule or mass requiring a lobectomy (removal of a lobe of the lung) - The nodule is located in the outer portion of the lung (not near the central airways) - There is no evidence that the cancer has spread (no metastasis) **You may NOT be eligible if...** - You received chemotherapy or radiation before the planned surgery - Your tumor is in a central location (near the main airways of the lung) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERSubjects undergoing a lung specimen lymph node dissection

A lobectomy specimen's resection will undergo systematic lymph node dissection either by the patient's treating thoracic surgeon and/or by a member of the pathology team. The protocol for a standardized lymph node dissection consists of a series of blunt peribronchial dissections starting from the hilum to the periphery, with particular attention to points of airway bifurcation where intrapulmonary lymph nodes aggregate. By emphasizing the intrapulmonary lymph node map and a standardized dissection, the team will remove more lymph nodes from the lobectomy specimen, resulting in an accurate N staging.

OTHERControl group

Control group