Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects
Effectiveness of Combined Treatment of Bupropion and Nicotine Replacement Therapy in Hospitalized Subjects With Active Smoking in a Reference Center
National Institute of Respiratory Diseases, Mexico
134 participants
Jan 15, 2024
INTERVENTIONAL
Conditions
Summary
In the 20th century, tobacco caused the death of 100 million people worldwide and it is estimated that it will be responsible for 1 billion deaths in the 21st century. Currently 8 million people die each year from smoking, 7 million are associated with active smoking, thus being the main risk factor for loss of disability-adjusted life years for men and the ninth most important risk factor for women. In previous studies it has been reported that approximately 21% (14%-30%) of subjects who have required hospitalization are active smokers, being higher in men than in women (28% vs 14%). The initiation of treatment for smoking cessation in this group of subjects has shown an effectiveness rate of up to 65% to maintain abstinence 6 to 12 months after discharge. The effectiveness has been analyzed in scenarios with only brief advice, in some others with the use of medications such as varenicline, bupropion and nicotine replacement therapy, however, the interventions have not been standardized for adequate analysis, which could contribute to the different results.
Eligibility
Inclusion Criteria1
- \>18 years Active smokers (consumption of more than 100 cigarettes in their entire life, and who have consumed cigarettes in the last 30 days) Hospitalized subjects Informed consent
Exclusion Criteria3
- Subjects who have had pharmacological treatment to stop smoking in the last month
- Subjects with contraindications for medications.
- Sample size calculation, 80% power, unilateral, due to difference in proportions, estimated loss of 25%.
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Interventions
Bupropion will be added at doses of 150 mg to 300 mg per day in addition to nicotine replacement therapy, counseling and cognitive behavioral therapy
Nicotine replacement therapy (Nicotine patches) plus counseling and cognitive behavioral therapy
Locations(1)
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NCT06254001