Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery
Mechanisms and Outcomes in Patients With Arrhythmic Mitral Valve Prolapse Undergoing Mitral Valve Surgery
Karolinska Institutet
90 participants
Feb 21, 2024
OBSERVATIONAL
Conditions
Summary
Study objectives: * To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline to 6 months after surgery * To characterize the molecular landscape of arrhytmogenic MVP Study design: -Prospective explorative observational study Study population: -90 patients with arrhytmogenic MVP and without arrhytmogenic MVP (controls) eligible for mitral valve surgery for mitral regurgitation will be enrolled. All patients will be evaluated with cardiac magnetic resonance (CMR) imaging and continuous seven day arrhythmic monitoring before and at 6 months after mitral valve surgery
Eligibility
Plain Language Summary
Simplified for easier understanding
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Interventions
Mitral valve repair or replacement of mitral regurgitation
Locations(1)
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NCT06255457