RecruitingNCT06255457

Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery

Mechanisms and Outcomes in Patients With Arrhythmic Mitral Valve Prolapse Undergoing Mitral Valve Surgery

Sponsor

Karolinska Institutet

Enrollment

90 participants

Start Date

Feb 21, 2024

Study Type

OBSERVATIONAL

Conditions

Mitral Regurgitation

Summary

Study objectives: * To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline to 6 months after surgery * To characterize the molecular landscape of arrhytmogenic MVP Study design: -Prospective explorative observational study Study population: -90 patients with arrhytmogenic MVP and without arrhytmogenic MVP (controls) eligible for mitral valve surgery for mitral regurgitation will be enrolled. All patients will be evaluated with cardiac magnetic resonance (CMR) imaging and continuous seven day arrhythmic monitoring before and at 6 months after mitral valve surgery

Eligibility

Min Age: 18 Years

Inclusion Criteria2

Age 18 and over
Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care

Exclusion Criteria9

Secondary mitral regurgitation
Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)
Co-existing moderate or severe aortic valve disease
Congenital heart disease
Inherited or acquired cardiomyopathy
Non-incidental or symptomatic coronary artery disease
Uncontrolled atrial fibrillation (resting heart rate > 100/min)
Pregnancy
Unable to undergo CMR