RecruitingNot ApplicableNCT06260683

A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-cigarettes on Smoking Behavior

A Comprehensive Evaluation of Tobacco-Flavored vs. Non-Tobacco Flavored E-Cigarettes on Smoking Behavior

Sponsor

Ohio State University Comprehensive Cancer Center

Enrollment

1,500 participants

Start Date

Apr 10, 2024

Study Type

INTERVENTIONAL

Conditions

Cigarette Smoking-Related Carcinoma

Summary

This clinical trial compares the use of tobacco flavored electronic cigarettes (ECs) vs. non-tobacco flavored ECs vs. nicotine replacement therapy (patches and lozenges) on smoking behavior in current cigarette smokers. ECs may reduce cigarette craving and withdrawal symptoms, increase motivation and confidence to stop cigarette smoking, and decrease cigarette smoking and dependence. By comparing participants' preferred flavor ECs (PEC) to tobacco flavor ECs (TEC) to NRT, researchers hope to determine the effect of EC flavors on appeal and use and learn how ECs affect smoking behaviors and health.

Eligibility

Min Age: 21 Years

Inclusion Criteria5

>= 21 years old
Smoke >= 5 cigarettes per day for the past year
Willing to use either an EC or NRT
Read and speak English
Have a smartphone

Exclusion Criteria12

Report currently using smoking cessation medications, NRT, or actively seeking treatment for smoking cessation
Current use of an EC > 4 days a month
Diagnosed medical conditions of lung disease, asthma, cystic fibrosis, heart disease or chronic obstructive pulmonary disease (COPD)
Unmanaged (unmedicated and/or without counseling) diagnosis of schizophrenia
History of cardiac event or distress within the past 3 months
Currently pregnant, planning to become pregnant within 6 months, or breastfeeding
High blood pressure not controlled by medications
Serious angina pectoris or chest pain
Stroke within the past three months
Known allergy to propylene glycol or vegetable glycerin
Serious underlying arrhythmias, irregular heartbeat or abnormal heart rhythm
Live in same household as another study participant