RecruitingNot ApplicableNCT06264336

Effects of High-intensity Gait Training on Fatigue, Gait, and Neuroplasticity in People With Multiple Sclerosis

Sponsor

University of Illinois at Chicago

Enrollment

20 participants

Start Date

Mar 1, 2024

Study Type

INTERVENTIONAL

Conditions

Multiple Sclerosis

Summary

Nearly 1 million individuals in the United States have multiple sclerosis, which causes fatigue and problems with walking. Fatigue and walking problems are poorly treated, but exercise training, particularly high-intensity walking exercise, may help. This provide insight into whether high-intensity walking exercise can improve fatigue and walking problems in people with multiple sclerosis, which could improve quality of life and reduce economic burden.

Eligibility

Min Age: 21 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether high-intensity walking (treadmill) training can reduce fatigue, improve walking ability, and promote brain changes in people with multiple sclerosis who have walking difficulties. **You may be eligible if...** - You are 21 or older - You have a confirmed diagnosis of multiple sclerosis - You have walking difficulties (moderate disability level) - You have been on the same MS medication for at least 6 months - You can walk for 6 minutes at your own pace (walking aids are allowed) - You experience significant fatigue (fatigue severity score of 4 or higher) **You may NOT be eligible if...** - You have had an MS relapse in the past 30 days - You are pregnant - You have another neurological disorder in addition to MS - You have uncontrolled heart, lung, or metabolic conditions - You have significant cognitive or communication difficulties Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALtreadmill training

Participants will undergo 12 sessions (4 weeks, 3 sessions/week) of treadmill training. During each session, participants will walk for 40 min. with 5 min. of warmup and cooldown at 50% of maximal walking speed (tested each week) with 30 min. of training interposed. The type of training will be determined by the assigned treatment arm.

Locations(1)

University of Illinois Chicago

Chicago, Illinois, United States

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NCT06264336

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