RecruitingPhase 2NCT06266338

Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)

A Phase 2A, Prospective, Open Label, Single Institution Study of Pembrolizumab and Lenvatinib in Metastatic and Recurrent Cervix Cancer (LenPem Cervix)


Sponsor

University of Texas Southwestern Medical Center

Enrollment

30 participants

Start Date

Mar 11, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The main purpose of this study is to gather information about an investigational drug combination, Lenvatinib in combination with pembrolizumab, that may help to treat cervical cancers. In this study, we are looking to see whether the combination of lenvatinib and pembrolizumab has any effect on slowing tumor growth in cervical cancer tumors.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing the combination of two cancer drugs — pembrolizumab (immunotherapy) and lenvatinib (targeted therapy) — in women with cervical cancer that has come back or spread and has already been treated with prior chemotherapy. **You may be eligible if...** - You are a woman, 18 or older - You have been diagnosed with recurrent or metastatic cervical cancer (squamous, adenocarcinoma, or adenosquamous) - You have received up to 2 prior lines of chemotherapy for advanced or recurrent disease - You may have received prior immunotherapy or bevacizumab **You may NOT be eligible if...** - You have uncontrolled or serious health conditions such as severe heart disease, uncontrolled high blood pressure, or active significant bleeding - You are pregnant or breastfeeding - You have active, untreated brain metastases Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

Interested in this trial?

Get notified about updates and connect with the research team.

Interventions

DRUGPembrolizumab

200 mg IV q 3 weeks

DRUGLenvatinib

20 mg PO daily


Locations(1)

UT Southwestern Medical Center

Dallas, Texas, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

Visit

NCT06266338


Related Trials