Study of AZD0754 in Participants With Metastatic Prostate Cancer

This study is testing a new drug called AZD0754 in patients with metastatic prostate cancer that has continued to grow despite hormone therapy (castration-resistant), to evaluate how safe it is and whether it can slow or stop cancer progression. **You may be eligible if...** - You are 18 or older - You have metastatic prostate cancer confirmed by biopsy - Your cancer continues to grow despite having very low testosterone levels (castration-resistant) - Your PSA level is 1 ng/mL or higher - Your cancer has shown evidence of progression in the past 6 months - You are continuing androgen deprivation therapy (e.g., LHRH analog injections) **You may NOT be eligible if...** - You have small cell or neuroendocrine prostate cancer - You have had prior treatment with certain PARP inhibitors or platinum chemotherapy - You have active serious infections or significant organ problems Talk to your doctor to see if this trial is right for you.